Key Cannabinoids

Cannabis, also known as marijuana, is a plant that has been used for medicinal, recreational, and industrial purposes for thousands of years. It contains a variety of chemical compounds, including cannabinoids, terpenes, and flavonoids.

Cannabinoids are the most well-known compounds in cannabis, interacting with the body's endocannabinoid system. The two most studied cannabinoids are THC and CBD.

The ECS is a complex cell-signaling system identified in the early 1990s by researchers exploring THC. It plays a role in regulating a range of functions and processes, including:

• Sleep
• Appetite
• Pain
• Immune response

The ECS involves three core components:

1. Endocannabinoids: Naturally produced molecules in your body (e.g., anandamide and 2-AG).
2. Receptors: Cannabinoid receptors on the surface of cells, primarily CB1 (found mostly in the central nervous system) and CB2 (found mostly in the peripheral nervous system and immune cells).
3. Enzymes: Break down endocannabinoids once they have carried out their function.

The legal status of cannabis varies significantly worldwide and even within countries.

The U.S. federal government classifies cannabis as a Schedule I controlled substance. However, many states have legalized it for medical and/or recreational use.

Internationally, laws range from full legalization to strict prohibition. The status continues to evolve as more countries explore regulation.

Methods of consumption influence the onset, duration, and intensity of effects.

• Inhalation: Smoking or vaping provides rapid onset.
• Edibles: Products infused with cannabis, which have a delayed onset but longer duration.
• Tinctures/Oils: Liquid extracts placed under the tongue for sublingual absorption.

Topicals: Creams or balms applied to the skin for localized relief.